Sequence requirements for oligodeoxyribonucleotide inhibitory activity
نویسندگان
چکیده
منابع مشابه
Sequence requirements for oligodeoxyribonucleotide inhibitory activity.
Inhibitory oligonucleotides (IN-ODN) differing from stimulatory CpG ODN (ST-ODN) by as few as two bases can block ST-ODN-induced proliferation, apoptosis protection and IL-6 secretion in B lymphocytes and the production of IL-12p40 by non-B cells. The main objective of this study was to determine the ODN sequence requirements for inhibition in mice. Starting with a strongly inhibitory 15-mer pr...
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Several electrophoretic and chromatographic systems have been investigated and compared for sequence analysis of oligodeoxyribonucleotides. Three systems were found to be useful for the separation of a series of sequential degradation products resulting from a labeled oligonucleotide: (I) 2-D electrophoresisdagger; (II) 2-D PEI-cellulose; and (III) 2-D homochromatography. System (III) proved ge...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2005
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxh222